Noninvasive Analysis Using Data-Independent Acquisition Mass Spectrometry: New Epidermal Proteins That Reveal Sex Differences in the Aging Process

Figure 3

(a) Proteins possessing more than 10 neighboring proteins in the protein-protein interaction network analysis. (b–e) Network analysis of gene expression was performed for the 21 selected genes, where the genes we selected were indicated by red circles. The pathway with the most genes involved in (b) is complement and coagulation cascades; the pathway with the most genes involved in (c) is cardiomyopathy; the pathway with the most genes involved in (d) is ferroptosis; and the pathway with the most genes involved in (e) is apoptosis and autophagy. (Supplementary Tables 5, 6, 7, and 8 for details).

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