Synthesis and Biological Screening of New 4-Hydroxycoumarin Derivatives and Their Palladium(II) Complexes

<div>Zebrafish toxicity testing. (a) Representative image of unsuccessful hatching upon treatment of zebrafish embryos with 100 <i>μ</i>M of coumarin complex C2 (left panel) compared to successful hatching of nontreated embryos (right panel). (b) Skeletal (asterisk) and cardiovascular abnormalities (arrow) detected at 10 <i>μ</i>M concentration of either C1 or C2. (c) Representative images of normal development of nontreated embryos or treated with 1 <i>μ</i>M of C1 or C2. (d) Lethal effect of starting coumarin compound (AHC) detected within first 24 h, at any tested concentration.</div>

Oxidative Medicine and Cellular Longevity

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Figure 4

Figure 4: Synthesis and Biological Screening of New 4-Hydroxycoumarin Derivatives and Their Palladium(II) Complexes 