Therapeutic Value of miRNAs in Coronary Artery Disease

Table 2

Therapeutic role of miRNAs in atherosclerosis.

miRNAs	Effects and targets	References
Mimic-miR-30c	Reduces hyperlipidemia and atherosclerosis development through decreasing lipid synthesis and apolipoprotein B (APOB) secretion by inhibiting microsomal transfer protein (MTP) activity in ApoE−/− mice	[50]
Mimic-microRNA-30c-5p	Markedly reduces atherosclerosis in human aortic endothelial cells (HAECs) via downregulation of the inflammatory NLRP3 protein expression and forkhead box O3 (FOXO3)	[51]
Anti-miR-143-3p	Increases HDL-cholesterol levels and prevents dyslipidemia and atherosclerosis progression through angiopoietin-like protein 8 (ANGPTL8) in liver cells	[52]
Anti-microRNA-23a-5p	Significantly protects against atherosclerosis and enhances plaque stability in ApoE−/− mice via upregulation of cholesterol transporter ABCA1/G1	[53]
Anti-miR-33	Increases HDL levels, enhances cholesterol efflux, inhibits inflammation and the transformation of macrophages into foam cells, and reduces atherosclerosis plaque progression in ApoE−/− mice	[54]
Anti-miR-155	Reduces atherosclerosis lesion formation in ApoE−/− mice by reducing inflammatory responses of macrophages and enhances cholesterol efflux through targeting suppressor of cytokine signaling 1 (SOCS-1)	[57]
Mimic-miR-181b	Decreases endothelial nuclear factor-κB (NF-κB) activation, suppresses leukocyte recruitment, and prominently declines atherosclerosis in mice through modulating its target gene, importin-α3	[58]
Mimic-miR-181b	Suppresses NF-κB-linked proteins that include tissue factor, vascular cell adhesion molecule-1, E-selectin, and intercellular adhesion molecule-1 and decreases arterial thrombus formation by ~73% via caspase recruitment domain family member 10 (Card10) proteins	[59]
Mimic-miR-181b	Delays unstable plaque progression in patients with unstable coronary artery disease by inhibiting endothelial cell proliferation and migration and angiogenesis through STAT3 transcriptional activity in EA.hy926 cells	[61]