Therapeutic Value of miRNAs in Coronary Artery Disease

Table 3

Role of miRNAs in coronary artery disease (CAD).

miRNAs	Target gene(s)	Inhibitory/activating	Actions	References
miR-34a	Silent information regulator protein-1 (SIRT1)	Inhibition	Protects endothelial function in CAD patients	[67]
miR-361-5p	Vascular endothelial growth factor (VEGF)	Inhibition	Induces ~90% improvement in local circulation of the ischemic mouse limbs	[71]
miR-23a	Epidermal growth factor receptor (EGFR)	Inhibition	Improves blood flow recovery in ischemic area	[73]
miR-135b, miR-499a	Myocyte enhancer factor 2C (MEF2C)	Overexpression	Promotes endothelial cells and vascular smooth muscle cell proliferation	[74]
miR-502	GTPase Rab1b and adaptor-related protein complex 2 subunit β1 (AP2B1)	Inhibition	Suppresses autophagy	[75]
miR-33a and miR-33b	Carnitine O-octanoyltransferase (CROT), carnitine palmitoyltransferase 1A (CPT1A), hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit β (HADHB), and protein kinase AMP-activated catalytic subunit α1 (PRKAA1)	Inhibition	Reduces VLDL and elevates HDL concentrations	[76]
miR-939	γ-Catenin	Overexpression	Remarkable role in angiogenesis	[77]
miR-155	Mitogen-activated protein kinase kinase kinase 10 (MAP3K10)	Inhibition	Prevents the development and progression of atherosclerosis and CAD	[78]
miR-126	C-X-C motif chemokine ligand 12 (CXCL12)	Overexpression	Significantly prevents atherosclerotic CAD	[79]
miR-21	Apoptosis-regulating proteins Bcl2 and phosphatase and tensin homologue (PTEN)	Inhibition	Prevents neointimal lesion formation and postangioplasty restenosis	[80]
miR-146	Vascular endothelial growth factor A (VEGF-A)	Overexpression	Increases coronary collateral circulation in ischemic cardiac tissue	[81]
miR-20	Endothelin 1 (ET-1), thromboxane A2 (TXA2) synthesizing enzymes, angiotensin II (ANGII), PTEN	Overexpression	Markedly reduces the incidence of exercise-associated CAD	[82]