Emodin-Induced Oxidative Inhibition of Mitochondrial Function Assists BiP/IRE1α/CHOP Signaling-Mediated ER-Related Apoptosis

Figure 1

Emodin inhibited the viability of L02 cells via enhancing intracellular ROS. (a) Chemical structure of emodin. (b) Cell viability of L02 cells after 24 h emodin treatment was detected using the CCK-8 assay. (c, d) Intracellular ROS levels in L02 induced by emodin (×200), scale bar: 100 μm. (e, f) Intracellular ROS levels in L02 treated with NAC, emodin, or NAC+emodin (×200), scale bar: 100 μm. (g) Cell viability of L02 cells treated with NAC, emodin, or NAC+emodin. , , , and vs. the control groups; , vs. the emo groups.

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