P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-<i>κ</i>B/NLRP3 Crosstalk

<div>NF-<i>κ</i>B or NLRP3 inhibitors attenuate pyroptotic inflammation. (a) Cell viability of chondrocytes treated with MIA (1.5 <i>μ</i>M) with or without A740003 (20 <i>μ</i>M), BzATP (50 <i>μ</i>M), BzATP+Bay 11-7082 (10 <i>μ</i>M), or BzATP+CY-09 (10 <i>μ</i>M) for 12 h. (b) Double-positive staining rate for activated caspase-1 and propidium iodide (PI). (c) Scatter plot evaluating cell viability measured by flow cytometry. (d) ELISA analysis of extracellular inflammatory factor IL-1<i>β</i>. (e) Cell damage analyzed by LDH assay. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-<i>κ</i>B/NLRP3 Crosstalk 

Oxidative Medicine and Cellular Longevity

P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-κB/NLRP3 Crosstalk

Figure 3