Quercetin Reverses Cardiac Systolic Dysfunction in Mice Fed with a High-Fat Diet: Role of Angiogenesis

Figure 3

High-fat diet induces cardiomyocyte hypertrophy and cardiac fibrosis in C57BL/6J mice, which quercetin significantly improves. Representative histological sections of hematoxylin-eosin (HE) staining (a) and wheat germ agglutinin (WGA) staining (b) show cardiomyocyte hypertrophy. Control+vehicle (CV; HE; WGA), control+quercetin (CQ; HE; WGA), high-fat+vehicle (HV; HE; WGA), high-fat+quercetin (HQ; HE; n =6 WGA), and representative histological sections of Masson’s Trichrome staining and quantification show increased myocardial perivascular (c) and interstitial (d) fibrosis in high-fat diet-fed mice. CV, ; CQ, ; HV, ; HQ, ; Data are . vs. CV. ^# vs. CQ. ^ vs. HV.

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