Decitabine Downregulates TIGAR to Induce Apoptosis and Autophagy in Myeloid Leukemia Cells

Figure 6

The inhibition of the glycolysis pathway attenuates the effects of DAC. The ROS levels (a), cell cycle distribution (b), and apoptosis (c) of HL-60 cells detected by FCM after TIGAR knockdown, and 0.5 μM of DAC treatment, in the presence or absence of 1 mg/ml of 2-DG are shown. The values were presented as the (SD) of three independent experiments. , , , NS compared to the control group.

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