Decitabine Downregulates TIGAR to Induce Apoptosis and Autophagy in Myeloid Leukemia Cells

<div>The TIGAR knockdown enhanced the DAC-induced autophagy activation. HL-60 cells were treated with 0.25, 0.50, and 1.00 <i>μ</i>M of DAC for 24 hours, with or without TIGAR knockdown. The levels of LC3, Beclin-1, and ATG5 were detected by western blot (a) and qPCR (b). 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Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: Decitabine Downregulates TIGAR to Induce Apoptosis and Autophagy in Myeloid Leukemia Cells 