Decitabine Downregulates TIGAR to Induce Apoptosis and Autophagy in Myeloid Leukemia Cells

Figure 8

The TIGAR knockdown enhanced the DAC-induced autophagy activation. HL-60 cells were treated with 0.25, 0.50, and 1.00 μM of DAC for 24 hours, with or without TIGAR knockdown. The autophagosome formation was detected by transmission electron microscopy. Scale bar: 500 nm. Red arrows indicate autophagosomes.