Hydrogen Sulfide Is a Regulator of Hemoglobin Oxygen-Carrying Capacity via Controlling 2,3-BPG Production in Erythrocytes

<div>Reduced H<sub>2</sub>S level contributes to increased 2,3-BPG production and decreased Hb-O<sub>2</sub> affinity in erythrocytes of <i>Cse</i><sup>-/-</sup>mice. WT and <i>Cse</i><sup>-/-</sup> mice were administered with saline or GYY4137 (133 <i>μ</i>mol/kg). (a–c) Erythrocytes were isolated for determination of the 2,3-BPG level (a) and oxygen dissociation curve ((b) P50 value; (c) representative trace of the oxygen dissociation curve) 24 h after injection. 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Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: Hydrogen Sulfide Is a Regulator of Hemoglobin Oxygen-Carrying Capacity via Controlling 2,3-BPG Production in Erythrocytes 