Research Article
Hydrogen Sulfide Is a Regulator of Hemoglobin Oxygen-Carrying Capacity via Controlling 2,3-BPG Production in Erythrocytes
Figure 2
Levels of 2,3-BPG and P50 are dependent on H2S produced by peripheral tissues but not related to the blood pressure in Cse-/- mice. (a–c) BMT was performed between the WT and Cse-/- mice. Eight weeks after BMT, the “WT-to-WT” and “Cse-/--to-WT” mice were administered with saline, while the “WT-to-Cse-/-” mice were administered with saline or GYY4137 (133 μmol/kg). Circulatory H2S levels (a), erythrocyte 2,3-BPG levels (b), and P50 (c) were examined 24 h after treatment. (d–f) WT and Cse-/- were treated with pinacidil (2.8 μmol/kg) or saline. The blood pressure (d), erythrocyte 2,3-BPG levels (e), and P50 (f) were examined 24 h after treatment. Data are expressed as (). , .
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