The Protective Effect of Cyanidin-3-Glucoside on Myocardial Ischemia-Reperfusion Injury through Ferroptosis

<div>The effect of C3G on USP19/Beclin1-mediated ferroptosis in heart tissues of I/R-induced rats: (a) the effect of C3G on the expressions of USP19, Beclin1, NCOA4, LC3II/LC3I, GPX4, TfR1, and FTH1; (b) the relative levels of USP19, Beclin1, NCOA4, LC3II/LC3I, GPX4, TfR1, and FTH1 versus GAPDH; (c) the effect of C3G on the K11-linked deubiquitination by co-IP; (d) the relative levels of Beclin1-(K11-Ub)/Beclin1. <span class="nowrap"><svg height="13.532pt" id="M15" style="vertical-align:-3.4295pt" version="1.1" viewbox="-0.0498162 -10.1025 50.6052 13.532" width="50.6052pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: The Protective Effect of Cyanidin-3-Glucoside on Myocardial Ischemia-Reperfusion Injury through Ferroptosis 