Melatonin Attenuates Diabetic Myocardial Microvascular Injury through Activating the AMPK/SIRT1 Signaling Pathway

<div>Melatonin attenuated HG-stimulated apoptosis in CMECs. (a) Annexin V-FITC/PI staining to determine apoptosis. (b) Quantification of apoptotic percentage. (c) Western blot to analyze the Bcl-2 expression. (d) Representative pictures of JC-1 staining (magnification, 400x). 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NG: normal glucose; M: mannitol; HG: high glucose; Mel: melatonin.</div>

Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Melatonin Attenuates Diabetic Myocardial Microvascular Injury through Activating the AMPK/SIRT1 Signaling Pathway 