The Landscape of Interactions between Hypoxia-Inducible Factors and Reactive Oxygen Species in the Gastrointestinal Tract

<div>HIF-1<i>α</i> regulated by ROS plays a role in gastrointestinal diseases. HIF-1<i>α</i> regulated by ROS contributes to rectal cancer, gastric carcinogenesis, gastric mucosal lesions, duodenal ulceration, and disruption/protection of intestinal tight junctions.</div>

Oxidative Medicine and Cellular Longevity

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Figure 2

Figure 2: The Landscape of Interactions between Hypoxia-Inducible Factors and Reactive Oxygen Species in the Gastrointestinal Tract 