Green Tea (Camellia sinensis) Extract Increased Topoisomerase IIβ, Improved Antioxidant Defense, and Attenuated Cardiac Remodeling in an Acute Doxorubicin Toxicity Model

Figure 2

Plot and western blot images showed the expression of proteins in the heart forty-eight hours after injection with doxorubicin (DOX). Groups: C: control; GT: green tea; D: doxorubicin; DGT: doxorubicin+green tea. PPARα: peroxisome proliferator-activated receptor; AMPKα: activated protein kinase; TNFα: tumor necrosis factor-alpha; P-akt/T-akt: protein kinase B phosphorylated; Top2-β: topoisomerase IIβ. : value for interaction between factors GT and DOX. : value for the differences between the groups with GT and without GT; : value for the differences between the groups with DOX and without DOX. For PPARα: and AMPKα: , there were interactions between GT and DOX. Thus, for PPARα and AMPKα, we considered , , , and . Comparisons without interaction considered the groups ^#; ^&GT . For TNFα, and for P-akt/T-akt, . For Top2-β, .