Proteomic Analysis Revealed the Characteristics of Key Proteins Involved in the Regulation of Inflammatory Response, Leukocyte Transendothelial Migration, Phagocytosis, and Immune Process during Early Lung Blast Injury

Figure 5

Blast exposure significantly altered the expression of key proteins involved in leukocyte transendothelial migration. (a) Western blot analysis of the expression key proteins related to leukocyte transendothelial migration after blast exposure. (b) CD11a expression levels were significantly increased at 24 h, 48 h, 72 h, and 1 week after blast exposure compared with the control (Ctrl) group. (c) Rac2 expression levels were significantly increased at 24 h and 48 h after blast exposure compared with the control group. (d) PKCα expressions were significantly increased at 24 h, 48 h, and 72 h after blast exposure compared with the control group. All experiments were repeated at least three times. All data were expressed as () and analyzed by the one-way ANOVA test, followed by Tukey’s test for multiple comparisons. Differences were considered statistically significant at for all analyses. vs. the control group.

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