The Roles of FGF21 and ALCAT1 in Aerobic Exercise-Induced Cardioprotection of Postmyocardial Infarction Mice

Figure 1

The protective of aerobic exercise on the MI heart in WT and fgf21^-/- mice. (a) The myocardial infarct size was measured with Masson’s trichrome staining. The images show that the fibrosis marker was stained in blue, whereas cardiac muscle fibers in red and nuclei in dark brown. Above: original magnification ×4; middle: original magnification ×10; below: original magnification ×20. Scale bar: 10 μm. (b) Quantification of collagen volume of fraction (CVF%). (c) Echocardiography. (d) Left ventricular end diastolic diameter (LVIDd) and left ventricular systolic diameter systole (LVIDs). (e) Left ventricular ejection fraction (EF) and left ventricular short axis (FS). CVF: collagen volume fraction; EF: ejection fraction%; FS: fractional shortening%; LVIDd: left ventricular internal diameter diastole; LVIDs: left ventricular internal diameter systole. S: sham group; ME: MI + aerobic exercise group. Data presented are . One-way ANOVA with post hoc LSD multiple-comparison test. , .

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