The Roles of FGF21 and ALCAT1 in Aerobic Exercise-Induced Cardioprotection of Postmyocardial Infarction Mice

<div>Aerobic exercise training significantly inhibited oxidative stress and ER stress-induced apoptosis partly via FGF21. (a, b) Western blotting images showed the phosphorylation levels of IRE1<i>α</i> and JNK, and the protein levels of IRE1<i>α</i>, JNK, GRP78, CHOP, Bax/Bcl-2 ratio, c-caspase3, SOD2, and ALCAT1. (c, d) TUNEL staining: TUNEL-positive granules in red and DAPI in blue. Original magnification ×10. (e) MDA content in the myocardium. (f) Enzyme activity of CAT in the myocardium. Scale bar: 200 px. ME: MI + aerobic exercise group. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: The Roles of FGF21 and ALCAT1 in Aerobic Exercise-Induced Cardioprotection of Postmyocardial Infarction Mice 