Review Article

Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma

Table 3

Medicinal plants and their bioactive compounds used in radiotherapy and chemotherapy.

Plants as radioprotector/radiosensitizer in HCC
Amaranthus paniculatus Linn.Decreases the depleted level of endogenic antioxidant enzymes during radiotherapy of mice liver.
Coronopus didymus (L.)Enhance the level of antioxidant enzymes in the liver of mice.
Grewia asiatica L.Augmented the SOD, CAT, and GSH levels in the liver of irradiated mice.
Glycyrrhiza glabra L.It protected plasmid DNA and reduced the liver microsomal LPO level in rat from irradiation.
Hypericum perforatum L.In vitro and in vivo studies show the increased level of SOD, CAT, GSH-Px, and GSH during radiation therapy
Pilea microphylla (L.) Liebm.Increased level of endogenous antioxidant enzyme levels in the liver of mice.
Rosmarinus officinalis L.Augmented the SOD, CAT, and GSH levels in blood and liver of mice during the radiation therapy.
Xylopia aethiopica (Dunal) A.Rich.Protect the liver of rat from γ-radiation
Bioactive phytomolecules as adjunct with chemotherapy
CurcuminUsed as an adjuvant with vinorelbine chemotherapy and enhances the antiproliferative effect of drugs.
QuercetinUsed as an adjunct in doxorubicin, busulfan, and cisplatin chemotherapy. It also increased cytotoxic effects of these drugs and protect from drug-induced nephrotoxicity.
GinsenosidesUsed as an adjunct with cisplatin and 5-FU chemotherapy and enhanced antiproliferative effect.