Oxidative Stress Profile of Mothers and Their Offspring after Maternal Consumption of High-Fat Diet in Rodents: A Systematic Review and Meta-Analysis

Table 2

Oxidative stress repercussions from offspring.

References

Animal

Kcal of fat/main fat source

Maternal HFD consumption (days)

Sex offspring

Death age (days)

Outcomes of offspring

Sample evaluated

MDA

8-OHdG

ROS

SOD

CAT

GPX

Thiols

Lin et al., [25]

Rats (Sprague–Dawley)

40%/lard

19

M/F

1

NM

NM

NM

↓

NM

NM

NM

Liver

Emiliano et al., [23]^a

Rats (Wistar)

47%/lard

21

F

90

↔

NM

NM

↓

↓

↔

NM

Blood

Emiliano et al., [23]^b

Rats (Wistar)

47%/lard

21

F

180

↑

NM

NM

↓

↓

↓

NM

Blood

Emiliano et al., [23]^c

Rats (Wistar)

47%/lard

21

F

90

↑

NM

NM

↓

↓

↓

NM

Mesentery

Emiliano et al., [23]^d

Rats (Wistar)

47%/lard

21

F

180

↑

NM

NM

↓

↓

↓

NM

Mesentery

Resende et al., [37]^a

Rats (Wistar)

47.40%/lard

21

M

90

↑

NM

NM

↓

↓

↓

NM

Blood

Resende et al., [37]^b

Rats (Wistar)

47.40%/lard

21

M

180

↑

NM

NM

↓

↓

↓

NM

Mesentery

Resende et al., [37]^c

Rats (Wistar)

47.40%/lard

21

M

90

↑

NM

NM

↓

↓

↓

NM

Blood

Resende et al., [37]^d

Rats (Wistar)

47.40%/lard

21

M

180

↑

NM

NM

↓

↓

↓

NM

Mesentery

Zhang et al., [42]^a

Rats (Sprague–Dawley)

45%/lard

42

M

84

↔

NM

NM

NM

NM

NM

NM

Blood

Zhang et al., [42]^b

Rats (Sprague–Dawley)

45%/lard

42

M

84

↑

NM

NM

NM

NM

NM

NM

Liver

Mdaki et al., [35]

Rats (Sprague–Dawley)

40%/oil vegetable+animal fat

49

M/F

1

↑

NM

NM

NM

NM

NM

NM

Cardiomyocyte

Gray et al., [33]

Rats (Sprague–Dawley)

45%/lard

52

M

140

NM

NM

↔

NM

NM

NM

NM

Mesenteric vessels

Miranda et al., [36]^a

Rats (Wistar)

29%/lard

98

M

180

NM

NM

NM

↓

↓

↓

↓

Liver

Miranda et al., [36]^b

Rats (Wistar)

29%/lard

98

F

180

NM

NM

NM

↓

↓

↔

↔

Liver

Oliveira et al., [46]

Rats (Wistar)

28.6%/lard

98

M

46

NM

NM

NM

↔

↔

↔

NM

Liver

Rodriguez-Gonzalez et al., [38]^a

Rats (Wistar)

46%/lard

141

M

110

↑

NM

↑

↑

NM

↑

NM

Tests

Rodriguez-Gonzalez et al., [38]^b

Rats (Wistar)

46%/lard

141

M

110

↔

NM

NM

↔

NM

↔

NM

Sperm

Rodriguez-Gonzalez et al., [38]^c

Rats (Wistar)

46%/lard

141

M

450

↑

NM

↑

↑

NM

↑

NM

Tests

Rodriguez-Gonzalez et al., [38]^d

Rats (Wistar)

46%/lard

141

M

450

↑

NM

NM

↓

NM

↓

NM

Sperm

Rodriguez-Gonzalez et al., [38]^e

Rats (Wistar)

46%/lard

141

M

650

↑

NM

↑

↑

NM

↑

NM

Tests

Rodriguez-Gonzalez et al., [38]^f

Rats (Wistar)

46%/lard

141

M

650

↑

NM

NM

↓

NM

↓

NM

Sperm

Rodriguez-Gonzalez et al., [38]^a

Rats (Wistar)

46%/lard

141

M

110

↑

NM

NM

NM

NM

NM

NM

Blood

Rodriguez-Gonzalez et al., [38]^b

Rats (Wistar)

46%/lard

141

M

450

↑

NM

NM

NM

NM

NM

NM

Blood

Rodriguez-Gonzalez et al., [38]^c

Rats (Wistar)

46%/lard

141

M

650

↔

NM

NM

NM

NM

NM

NM

Blood

Rodriguez-Gonzalez et al., [38]^d

Rats (Wistar)

46%/lard

141

F

110

↔

NM

NM

NM

NM

NM

NM

Blood

Rodriguez-Gonzalez et al., [38]^e

Rats (Wistar)

46%/lard

141

F

450

↑

NM

NM

NM

NM

NM

NM

Blood

Rodriguez-Gonzalez et al., [38]^f

Rats (Wistar)

46%/lard

141

F

650

↔

NM

NM

NM

NM

NM

NM

Blood

Rodriguez-Gonzalez et al., [38]^g

Rats (Wistar)

46%/lard

141

M

110

↑

NM

↔

↔

NM

↑

NM

Liver

Rodriguez-Gonzalez et al., [38]^h

Rats (Wistar)

46%/lard

141

M

450

↑

NM

↑

↔

NM

↓

NM

Liver

Rodriguez-Gonzalez et al., [38]^i

Rats (Wistar)

46%/lard

141

M

650

↑

NM

↑

↔

NM

↓

NM

Liver

Rodriguez-Gonzalez et al., [38]^j

Rats (Wistar)

46%/lard

141

F

110

↑

NM

↔

↑

NM

↔

NM

Liver

Rodriguez-Gonzalez et al., [38]^k

Rats (Wistar)

46%/lard

141

F

450

↑

NM

↑

↔

NM

↔

NM

Liver

Rodriguez-Gonzalez et al., [38]^l

Rats (Wistar)

46%/lard

141

F

650

↑

NM

↑

↓

NM

↓

NM

Liver

c^a

Mice (C57BL/6)

45%/unidentified

42

M

21

↑

NM

↑

NM

NM

NM

NM

Liver

Cao et al., [43]^b

Mice (C57BL/6)

45%/unidentified

42

M

84

NM

NM

↔

NM

NM

NM

NM

Liver

Ito et al., [34]^a

Mice (C57BL/6)

31%/oil vegetable+animal fat

42

M/F

21

↔

NM

NM

NM

NM

NM

NM

Liver

Ito et al., [34]^b

Mice (C57BL/6)

31%/oil vegetable+animal fat

42

M/F

77

↔

NM

NM

NM

NM

NM

NM

Liver

Yokomizo et al., [41]^a

Mice (C57BL/6)

62.20%/lard

42

M

140

NM

↑

NM

NM

NM

NM

NM

Islet

Yokomizo et al., [41]^b

Mice (C57BL/6)

62.20%/lard

42

F

140

NM

↔

NM

NM

NM

NM

NM

Islet

Torrens et al., [39]^a

Mice (C57BL/6)

45%/lard

70

M

105

NM

NM

↑

NM

NM

NM

NM

Femoral artery

Torrens et al., [39]^b

Mice (C57BL/6)

45%/lard

70

M

210

NM

NM

↑

NM

NM

NM

NM

Femoral artery

Tozuka et al., [40]^a

Mice (C57BL/6)

57.50%/unidentified

79

M

1

↔

NM

NM

NM

NM

NM

NM

Blood

Tozuka et al., [40]^b

Mice (C57BL/6)

57.50%/unidentified

79

M

10

↑

NM

NM

NM

NM

NM

NM

Blood

Tozuka et al., [40]^c

Mice (C57BL/6)

57.50%/unidentified

79

M

21

↑

NM

NM

NM

NM

NM

NM

Blood

Tozuka et al., [40]^d

Mice (C57BL/6)

57.50%/unidentified

79

M

70

↔

NM

NM

NM

NM

NM

NM

Blood

Glastras et al., [32]

Mice (C57BL/6)

43%/unidentified

84

M

224

NM

↑

NM

NM

NM

NM

NM

Kidney

Glastras et al., [31]

Mice (C57BL/6)

43%/unidentified

84

M

224

NM

↑

NM

NM

NM

NM

NM

Kidney

Bringhenti et al., [30]

Mice (C57BL/6)

49%/lard

98

M

10

NM

NM

NM

↓

↔

↔

NM

Liver

MDA: malondialdehyde; 8-OHdG: 8-hydroxy-2-deoxyguanosine; ROS: reactive oxygen species; SOD: superoxide dismutase; CAT: catalase; GPx: glutathione peroxidase; NM: not measured.