GC-MS-Based Serum Metabolomic Investigations on the Ameliorative Effects of Polysaccharide from Turpiniae folium in Hyperlipidemia Rats

Table 1

Identified metabolites related to hyperlipidemia based on GC-MS.

	Metabolites	Ret. time (min)	RSD of QC ()	HFD vs. control			HFD+TFP vs. HFD
No.				value	FC	AUC	value	FC	AUC
1	Tagatose	19.652	9.153%	≤0.001	2.862	0.98	<0.05	0.631	0.73
2	Fructose	19.794	4.802%	<0.005	1.809	0.87	≤0.001	0.526	0.91
3	D-Mannose	19.876	5.981%	>0.05	1.199	0.70	>0.05	0.913	0.60
4	Glucose	20.020	2.706%	<0.01	1.270	0.83	<0.05	0.808	0.82
5	Allose	20.305	1.660%	≤0.001	2.660	1.00	>0.05	0.853	0.75
6	D-(-)-Ribose	16.907	7.565%	<0.05	1.324	0.80	<0.05	0.753	0.81
7	D-(+)-Galactose	21.723	11.369%	≤0.001	2.365	0.94	<0.01	0.529	0.89
8	Propanoic acid	7.098	3.604%	≤0.001	1.481	0.90	<0.01	0.749	0.83
9	Acetic acid	7.363	4.816%	>0.05	1.227	0.66	>0.05	0.766	0.73
10	Butanoic acid	8.159	5.728%	>0.05	0.926	0.43	<0.05	0.784	0.82
11	DL-β-Hydroxybutyric acid	8.718	4.097%	<0.05	1.262	0.82	<0.01	0.697	0.90
12	Succinic acid	11.247	7.611%	>0.05	1.388	0.70	>0.05	0.897	0.50
13	Glyceric acid	11.463	5.898%	<0.05	1.470	0.77	>0.05	0.872	0.57
14	2,3-Dihydroxybutanoic acid	11.670	6.510%	>0.05	1.235	0.68	>0.05	0.850	0.66
15	Aminomalonic acid	13.750	15.590%	<0.01	1.533	0.89	<0.01	0.655	0.86
16	Trans-9-octadecenoic acid	24.160	7.442%	≤0.001	2.515	1.00	≤0.001	0.412	1.00
17	Stearic acid (17 : 0)	24.470	6.800%	≤0.001	1.798	1.00	<0.01	0.723	0.90
18	Hexadecanoic acid	22.083	4.731%	≤0.001	1.709	1.00	<0.05	0.868	0.75
19	Threonic acid	15.133	6.778%	≤0.001	2.339	0.99	<0.01	0.559	0.83
20	Cis-5,8,11-eicosatrienoic acid	25.886	21.165%	<0.01	1.807	0.81	<0.05	0.647	0.76
21	L-Alanine	7.790	8.732%	≤0.001	3.361	1.00	≤0.001	0.294	0.99
22	Norvaline	9.623	24.629%	≤0.001	3.821	1.00	≤0.001	0.254	1.00
23	Serine	10.321	7.818%	≤0.001	3.338	1.00	≤0.001	0.506	1.00
24	Threonine	10.923	10.560%	≤0.001	2.850	1.00	≤0.001	0.475	0.97
25	Glycine	11.117	7.384%	≤0.001	1.674	0.93	<0.05	0.767	0.79
26	L-5-Oxoproline	14.613	3.749%	<0.05	1.492	0.81	<0.01	0.646	0.80
27	Undecane	8.882	7.040%	>0.05	1.190	0.68	>0.05	0.836	0.60
28	Dodecane	9.474	7.120%	<0.05	1.673	0.84	<0.05	0.652	0.79
29	Pentacosane	10.703	5.265%	<0.01	1.603	0.89	>0.05	0.800	0.68
30	Hexadecane	17.410	6.431%	<0.01	1.552	0.88	>0.05	0.910	0.57
31	Eicosane	23.076	5.808%	≤0.001	2.746	1.00	>0.05	0.819	0.65
32	Undodecane	7.836	6.233%	<0.05	1.553	0.90	<0.05	0.709	0.73
33	Inositol	22.550	7.521%	>0.05	1.072	0.58	>0.05	0.890	0.59
34	Cholesterol	26.403	8.750%	≤0.001	2.309	1.00	≤0.001	0.393	1.00
35	2-Hydroxypyridine	6.743	16.887%	>0.05	1.315	0.80	>0.05	0.754	0.73
36	5,6-Dihydrouracil	8.406	1.620%	<0.05	1.384	0.76	<0.01	0.663	0.86
37	Urea	10.126	7.550%	≤0.001	2.709	1.00	≤0.001	0.392	1.00
38	Glycerol	10.548	5.632%	>0.05	1.176	0.68	>0.05	0.891	0.63
39	Phosphate	10.584	4.855%	≤0.001	1.687	0.98	<0.01	0.732	0.94
40	3-Aminopropionitrile	11.850	6.541%	>0.05	1.370	0.70	>0.05	0.684	0.72
41	1,5-Anhydrosorbitol	19.450	5.124%	≤0.001	1.746	0.91	<0.05	0.760	0.78
42	Tetracosane	25.523	12.435%	>0.05	1.037	0.50	>0.05	0.998	0.45