Geniposide Attenuates Hyperglycemia-Induced Oxidative Stress and Inflammation by Activating the Nrf2 Signaling Pathway in Experimental Diabetic Retinopathy

Figure 7

GEN decreased hyperglycemia-induced damage to the blood-retinal barrier (BRB). The mice in the normal and DM groups were treated with GEN. (a) Immunofluorescence was used to detect isolectin B4 (green) and GFAP (red) in the whole-mount retinas. White arrows show the exudate. (b–e) qRT-PCR was used to measure the mRNA expression of junction proteins, including VE-cadherin, claudin-5, occludin, and ZO-1, in the retinas of mice. /group.

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