Neuroprotective Effect of Ceftriaxone on MPTP-Induced Parkinson’s Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota

Figure 1

Ceftriaxone improved MPTP-induced motor dysfunction in PD mice. (a) Treatment schedule to explain the design of the whole experimental. (b) Ceftriaxone improved the bradykinesia mice induced by MPTP (pole test). (c) Ceftriaxone increased the total distance moved for PD mice (open-field test). (d) Ceftriaxone increased the distance in the central area moved for PD mice (open-field test). (e) Ceftriaxone increased the number of entries in central (open-field test). C group (), control group; M group (), MPTP group; MCEF group (), MPTP + ceftriaxone group; MCEFF group (), MPTP + ceftriaxone + fecal microbiota transplantation group; FMT group (), fecal microbiota transplantation group, FCEF group (), fecal microbiota transplantation group + ceftriaxone group. Data are presented as means ± SD. One-way repeated-measures ANOVA with Tukey’s test for multiple comparisons (b–e, respectively); , . CEF: ceftriaxone; MPTP: 1-methyl-4-phenyl-1, 2, 3, 6-tetra-hydropyridine.

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