Neuroprotective Effect of Ceftriaxone on MPTP-Induced Parkinson’s Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota

Figure 4

Gut microbial dysbiosis in PD mice is reduced by ceftriaxone. (a) The Chao1 index. (b) The Faith_pd index. (c) Petal map representation of OTUs. (d) PCoA of β diversity index. C group (), control group; M group (), MPTP group; MCEF group (), MPTP + ceftriaxone group; MCEFF group (), MPTP + ceftriaxone + fecal microbiota transplantation group; FMT group (), fecal microbiota transplantation group, FCEF group (), fecal microbiota transplantation group + ceftriaxone group. Data are presented as means ± SD. One-way repeated-measures ANOVA with Tukey’s test for multiple comparisons (a, b, respectively); , . CEF: ceftriaxone; MPTP: 1-methyl-4-phenyl-1, 2, 3, 6-tetra-hydropyridine.

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