Neuroprotective Effect of Ceftriaxone on MPTP-Induced Parkinson’s Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota

Figure 5

Effect of ceftriaxone on the relative abundance of gut microbial at phylum and genus level in feces of mice. The relative abundance of Firmicutes (a), Akkermansia (b), Proteus (c), Prevotella (d), Adlercreutzia (e), Bifidobacterium (f), Clostridium (g), Dorea (h), and Ruminococcus (i), in feces of PD mice. C group (), control group; M group (), MPTP group; MCEF group (), MPTP + ceftriaxone group; MCEFF group (), MPTP + ceftriaxone + fecal microbiota transplantation group; FMT group (), fecal microbiota transplantation group, FCEF group (), fecal microbiota transplantation group + ceftriaxone group. Data are presented as means ± SD. One-way repeated-measures ANOVA with Tukey’s test for multiple comparisons (a–i, respectively); ,. CEF: ceftriaxone; MPTP: 1-methyl-4-phenyl-1, 2, 3, 6-tetra-hydropyridine.

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