A Novel Systematic Oxidative Stress Score Predicts the Prognosis of Patients with Operable Breast Cancer

Table 4

Results of the univariate and multivariate Cox regression analyses for OS among the clinical characteristics and SOS.

Variables	Univariate Cox analysis		Multivariate Cox analysis
	HR (95% CI)	value	HR (95% CI)	value
Age		0.002		0.003
≤60	Reference		Reference -
>60	1.435 (1.155-1.783)		1.943 (1.247-3.027)
SOS		<0.001		<0.001
Low	Reference		Reference
High	2.389 (1.589-3.592)		2.096 (1.385-3.170)
Multifocality		0.786
No	Reference
Yes	1.177 (0.373-3.712)
Histological grade		0.019		0.430
I	Reference		Reference
II	1.704 (0.616-4.716)	0.305	1.411 (0.495-4.023)	0.520
III	2.719 (0.980-7.542)	0.055	1.749 (0.602-5.082)	0.304
VCE		<0.001		0.055
No	Reference		Reference
Yes	2.295 (1.558-3.380)		1.518 (0.992-2.322)
T stage		<0.001		<0.001
T1	Reference		Reference
T2	2.076 (1.310-3.290)	0.002	1.409 (0.876-2.265)	0.157
T3	4.812 (2.328-9.945)	<0.001	2.558 (1.190-5.497)	0.016
T4	7.158 (3.548-14.442)	<0.001	4.528 (2.150-9.540)	<0.001
N stage		<0.001		<0.001
N0	Reference		Reference
N1	1.680 (0.999-2.825)	0.050	1.567 (0.911-2.693)	0.104
N2	2.211 (1.217-4.017)	0.009	1.634 (0.856-3.121)	0.137
N3	5.911 (3.586-9.741)	<0.001	3.612 (2.056-6.346)	<0.001
IHC subtype		<0.001		0.032
Luminal A	0.185 (0.078-0.439)	<0.001	0.261 (0.107-0.642)	0.003
Luminal B	0.684 (0.414-1.131)	0.139	0.618 (0.362-1.056)	0.078
HER2+	0.683 (0.340-1.373)	0.284	0.625 (0.305-1.283)	0.201
TNBC	Reference		Reference