Hepcidin Promoted Ferroptosis through Iron Metabolism which Is Associated with DMT1 Signaling Activation in Early Brain Injury following Subarachnoid Hemorrhage

Figure 4

Both OSM and ebselen were used, the expression of hepcidin was improved (b), DMT1 was reduced (c), while GPX4 was increased (d),P <0.05 vs PBS + SAH group (, each group). 4 mg/kg ebselen could reverse the effects of 10 μg OSM on iron metabolism and ferroptosis (e–h), P <0.05 vs PBS + SAH group (, each group). 5 mg/kg heparin protected against ferroptosis, which reduced size of mitochondria in TEM after SAH, compared to the NS + SAH; 4 mg/kg ebselen decreased the size of mitochondria of ferroptosis after SAH, and it protected against ferroptosis, compared to the Abs+SAH; OSM 10 μg aggravated ferroptosis, which augmented the size of mitochondria in TEM after SAH, compared to the PBS + SAH (i) (, each group).

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