Review Article

Cold Physical Plasma in Cancer Therapy: Mechanisms, Signaling, and Immunity

Table 2

Clinical case series and trials on plasma therapy in medicine.

Study typeYearCondition# of pat.Plasma source/certificationOutcome with plasma treatmentAllocationRef.

Case series2015Infected wounds11kINPen MED (certified)Complete healing of the woundsN/A[242]
Case series2016Advanced head and neck cancer21kINPen MED (certified)No enhanced tumor growth and more apoptotic cell killN/A[121]
Case report2016Percutaneous driveline infection1kINPen MED (certified)Completed regression of local infectionN/A[243]
Case series2016Nonhealing wounds4kINPen MED (certified)Completed wound repairN/A[202]
Case series2017Nonhealing wounds6PlasmaDerm (certified)Completed remissionN/A[201]
Case series2017Actinic keratosis5FE-DBD (not certified)17 lesions: 9 showed full regression, 3 significantly improved, 5 showed no changeN/A[203]
Case series2018Warts2FE-DBD (not certified)Patient 1: wart cleared; patient 2: wart improved but not clearedN/A[205]
Case series2018Therapy-resistant corneal infections4kINPen MED (certified)Significantly elimination of pathogensN/A[244]
Case series2018Actinic keratosis7SteriPlas (certified)Overall decline of actinic keratosis characteristicsN/A[204]
Case series2020Warts5FE-DBD (not certified)4 warts cleared, 1 did not changeN/A[206]
Clinical trial2011-2012Chronic venous leg ulcers14PlasmaDerm (certified)Significantly improved ulcer size-reductionRandom[245]
Clinical trial2016-2020Actinic keratosis, acne, verruca plana100Plasma to treat skin lesions and acneSuccessful cure in most of themNonrandom[210]
Clinical trial2017-2020Facial wrinkles, rhytides55J-Plasma He-jet (FDA approved)Significant improvement, no serious adverse eventsN/A[246]
Clinical trial2017-2020Cervical intraepithelial neoplasia170Plasma treatmentPathological remission and HPV reductionNonrandom[208]
Clinical trial2017-2018Intact skin, experimental contaminant added to patient skin25PlasmaSafety, efficacy, and efficiency of plasma for burn wound treatmentNonrandom[247]
Clinical trial2017-2019Onychomycosis of toenail5Plasma treatmentMycological cure, evident nail growthN/A[248]
Clinical trial2019Wound healing100Cold argon PlasmaOngoing, no results have been yet reportedRandom[249]
Clinical trial2020Androgenetic alopecia40Plasma-treated aqueous-alcohol solutionOngoing, no results have been yet reportedN/A[211]