Vitexin Mitigates Myocardial Ischemia/Reperfusion Injury in Rats by Regulating Mitochondrial Dysfunction via Epac1-Rap1 Signaling

<div>Vitexin reduces ROS levels and apoptosis in H9c2 cells subjected to H/R injury. (a) Representative fluorescence images of ROS. (b) Quantitative graph of ROS levels. (c) Representative fluorescence images of Hoechst staining. (d) Quantitative graph of apoptotic cells. Western blot analyses showing the expression of (e) NOX4, (f) cleaved caspase-3, and (g) cleaved caspase-9. 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Vitexin Mitigates Myocardial Ischemia/Reperfusion Injury in Rats by Regulating Mitochondrial Dysfunction via Epac1-Rap1 Signaling 