The DNA Repair Enzyme XPD Is Partially Regulated by PI3K/AKT Signaling in the Context of Bupivacaine-Mediated Neuronal DNA Damage

Table 1

DNA repair gene expression in SH-SY5Y cells after exposure to bupivacaine was assessed with a cDNA plate array. The differentially expressed repair genes were mainly associated with the NER pathway.

C-vs-B (significant genes)	Pathways names	KEGG no.
SB, XPC-HR23B, XPD	Nucleotide excision repair	map03420
PTEN, RAD9, GADD45, ATR, P53	DDR(cell cycle)	map04110
DNA-PKcs	Nonhomologous end-joining	map03450
NTH1	Base excision repair	map03410