Ferroptosis: Opportunities and Challenges in Myocardial Ischemia-Reperfusion Injury

Figure 1

Cartoon depicting the possible mechanism and regulation of ferroptosis. Ferroptosis is mainly regulated by Fe homeostasis, lipid oxidation, System Xc^-, and VDAC. The most important in the ferroptosis signaling pathway is the production of iron ions and ROS. GPX-4 is a key regulator of ferroptosis. Inhibition of GPX-4 causes a large amount of lipid peroxides to aggregate, becoming a sign of ferroptosis.