Research Article
DNA-Aptamer Raised against Receptor for Advanced Glycation End Products Improves Survival Rate in Septic Mice
Figure 1
(a) ELISA for the binding of HMGB1 to vRAGE in the presence of control-aptamer or RAGE-aptamers. per group. compared with control-aptamer. (b) Experimental design 1. (c) The Kaplan-Meier survival analysis of mice injected with the indicated doses of LPS (each ). (d) Experimental design 2. (e) The Kaplan-Meier survival analysis of mice injected with LPS (20 μg/g-BW) plus vehicle (saline) in the presence or absence of the indicated doses of RAGE-aptamer or 40 pmol/g-BW of control-aptamer. per group. compared with control-aptamer.
(a) |
(b) |
(c) |
(d) |
(e) |