DNA-Aptamer Raised against Receptor for Advanced Glycation End Products Improves Survival Rate in Septic Mice

Figure 2

NF-κB p65, gene and protein expression of cytokines in serum and PBMCs of mice injected with saline (control), LPS (20 μg/g-BW) plus vehicle (positive control), LPS (20 μg/g-BW) plus 40 pmol/g-BW of control-aptamer, or LPS (20 μg/g-BW) plus 40 pmol/g-BW of RAGE-aptamer. (a) Total NF-κB p65 (left panel) and p-NF-κB p65 levels (right panel) in PBMCs. (b–e) Each left panel shows serum levels of TNF-α (b), IL-1β (c), IL-6 (d), and HMGB1 (e). per group. Each right panel shows gene expression levels of cytokines in PBMCs. per group. ^# and ^## compared with control, respectively. and compared with LPS plus control-aptamer-treated mice, respectively.

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