Vascular Risk Factors, Imaging, and Outcomes in Transient Ischemic Attack/Ischemic Stroke Patients with Neuroimaging Evidence of Probable/Possible Cerebral Amyloid Angiopathy
Table 5
Outcomes of CAA pattern in TIA/ischemic stroke patients at 3 months.
Outcomes
Death or disability (mRS 3-6)
No. of events
Crude RR (95% CI)
Adjusted RR (95% CI)
CMB statusa
No CMB ()
6/42
1 (reference)
1 (reference)
CMB ()
24/244
0.66 (0.25-1.71)
0.33 (0.11-0.98)
CMB counta
None ()
6/42
1 (reference)
1 (reference)
1-2 ()
13/165
0.51 (0.18-1.44)
0.27 (0.08-0.86)
3-10 ()
9/72
0.86 (0.28-2.60)
0.36 (0.10-1.31)
>10 ()
2/7
2.40 (0.38-15.33)
2.17 (0.30-15.92)
CMB topographya
None ()
8/67
1 (reference)
1 (reference)
Strictly lobar ()
11/133
0.67 (0.25-1.74)
0.50 (0.17-1.46)
Strictly deep ()
1/10
0.82 (0.09-7.35)
0.57 (0.06-5.73)
Mixed ()
10/76
1.12 (0.41-3.02)
0.70 (0.22-2.18)
cSS statusb
No cSS ()
18/192
1 (reference)
1 (reference)
cSS ()
12/93
1.43 (0.66-3.11)
2.01 (0.85-4.77)
cSS countb
None ()
18/192
1 (reference)
1 (reference)
1-2 ()
12/89
1.51 (0.69-3.28)
2.07 (0.88-4.90)
3-10 ()
0/4
—
—
>10 ()
0
0
0
cSS topographyb
None ()
18/192
1 (reference)
1 (reference)
Strictly lobar
6/35
2.00 (0.73-5.46)
3.68 (1.22-11.17)
Strictly deep ()
2/10
2.42 (0.48-12.26)
2.19 (0.59-17.35)
Mixed ()
4/48
0.88 (0.28-2.73)
0.92 (0.25-3.47)
Abbreviations: RR: relative risk; CMB: cerebral microbleed; cSS: cortical superficial siderosis. Multivariable analysis adjusted for age, HTN (history of hypertension), AF (history of atrial fibrillation), prior ischemic stroke, alcohol, glucose, 3 m MoCA, and Fazekas scale. aData were missing for 5 patients. bData were missing for 6 patients.
