Vascular Risk Factors, Imaging, and Outcomes in Transient Ischemic Attack/Ischemic Stroke Patients with Neuroimaging Evidence of Probable/Possible Cerebral Amyloid Angiopathy
Table 6
Outcomes of CAA pattern in TIA/ischemic stroke patients at 12 months.
Outcomes
Death or disability (mRS 3-6)
No. of events
Crude RR (95% CI)
Adjusted RR (95% CI)
CMB statusa
No CMB ()
8/42
1 (reference)
1 (reference)
CMB ()
29/239
0.59 (0.25-1.39)
0.26 (0.09-0.71)
CMB counta
None ()
8/42
1 (reference)
1 (reference)
1-2 ()
16/162
0.47 (0.18-1.18)
0.22 (0.08-0.65)
3-10 ()
12/70
0.88 (0.33-2.37)
0.34 (0.10-1.10)
>10 ()
1/7
0.71 (0.07-6.74)
0.46 (0.04-4.76)
CMB topographya
None ()
11/68
1 (reference)
1 (reference)
Strictly lobar ()
12/128
0.54 (0.22-1.29)
0.36 (0.14-0.96)
Strictly deep ()
2/10
1.30 (0.24-6.94)
0.94 (0.15-5.75)
Mixed ()
12/75
0.99 (0.40-2.41)
0.54 (0.19-1.53)
cSS statusb
No cSS ()
24/188
1 (reference)
1 (reference)
cSS ()
13/92
1.12 (0.54-2.33)
1.63 (0.73-3.67)
cSS countb
None ()
24/188
1 (reference)
1 (reference)
1-2 ()
13/89
1.17 (0.57-2.42)
1.66 (0.74-3.73)
3-10 ()
0/3
—
—
>10 ()
0
0
0
cSS topographyb
None ()
24/188
1 (reference)
1 (reference)
Strictly lobar ()
5/35
1.14 (0.40-3.22)
2.05 (0.67-6.29)
Strictly deep ()
2/10
1.71 (0.34-8.53)
2.09 (0.39-11.18)
Mixed ()
6/47
1.00 (0.38-2.61)
1.25 (0.42-3.73)
Abbreviations: RR: relative risk; CMB: cerebral microbleed; cSS: cortical superficial siderosis. Multivariable analysis adjusted for age, HTN (history of hypertension), AF (history of atrial fibrillation), prior ischemic stroke, alcohol, glucose, 3 m MoCA, and Fazekas scale. aData were missing for 10 patients. bData were missing for 11 patients.
