Central Nervous System Cell-Derived Exosomes in Neurodegenerative Diseases

Figure 2

Description of basic effect of cell type-specific exosomes on neurodegeneration. A certain color of exosomes represents that they are derived from the cell type with the corresponding color. Grey arrow means that no enough evidence or evidences contradicting to each other to draw the conclusion. Neuron or glia-derived exosomes could facilitate neuron degeneration. Astroglial exosomes may have neuroprotective property. The arrow of “microglial exosomes” to “loss of neuron” is marked grey since some evidence showed that microglia may not secret exosomes. The arrow of “oligodendrocyte-derived exosomes” to “loss of neuron” in marked grey since no enough researches focused on it. The arrow of “astrocyte-derived exosomes” to “preservation of neuron” is marked grey since no enough research supporting it.