Research Article
TRPV1 Channel Activated by the PGE2/EP4 Pathway Mediates Spinal Hypersensitivity in a Mouse Model of Vertebral Endplate Degeneration
Figure 8
L161982 treatment attenuated LSI-induced increase in neuronal excitability. (a) AP firing traces in L2 DRG neurons to 1 s, 300 pA depolarizing current injection. (b) Quantitative analysis of APs induced by step current injection in the sham+vehicle, LSI+vehicle, and LSI+L161982 groups. (c) Current threshold for APs in the sham+vehicle, LSI+vehicle, and LSI+L161982 groups ( cells per group). (d) Current clamp recordings with ramp current stimulation starting from 0 pA to 1000 pA of 500 ms duration. (e) Quantitative analysis of APs induced by ramp current stimulation (-19 cells per group). (f) The percentage of the neurons in response to ramp current stimulation ( cells per group). vs. sham+vehicle group, # vs. LSI+vehicle group.
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