The Involvement of the Oxidative Stress Status in Cancer Pathology: A Double View on the Role of the Antioxidants

Table 1

The role of oxidative stress on cancer development.

Cancer type	Sample collection	Models	Biomarkers	Reference
CRC	Human colon tissue, males, mean age 67 yrs, range 60-83, normal tissue () and cancerous tissue ()	In vivo	↑ROM; ↑MPO	Keshavarzian et al. (1992) [87]
	Human colorectal mucosal tissues, normal tissue () and tissue tumors ()	In vivo	↑MDA; ↑MPO; ↑PLA2	Otamiri et al. (1989) [88]
	Urine sample, cancer patients () and healthy(); Leukocyte DNA, healthy volunteers (), and malignant cancer patients ()	In vivo	↑8-oxoGua; ↑8-oxodG; ↑8-oxodG	Roszkowski et al. (2011) [91]
BC	Blood samples (plasma), women with breast cancer () and healthy controls ()	In vivo	↑FORT; ↓FORD	Tahari et al. (2013) [92]
	Blood samples, women BBC (), BC (), and healthy women ()	In vivo	↑8-OHdG	Eldin et al. (2019) [96]
	Urine sample, cancer patients () or healthy control ()	In vivo	↑8-OHdG	Yamamoto et al. (1996) [99]
	Blood samples (serum), BC patients () and healthy controls ()	In vivo	↑MDA; ↑GSSG; ↓GSH; ↓TAC; ↓GSH/GSSG	Hewala et al. (2019) [93]
PC	DU 145; LNCaP; PC3	In vitro	↑H2O2; ↑O2^-; ↑Nox	Kumar et al. (2008) [107]
	Blood samples (erythrocytes and plasma), PC patients (; age years), BPH patients (; age years), and healthy men (; age years).	In vivo	↓GPx3	Szewczyk-Golec et al. (2015) [108]
	Human prostate tissue, PC (), BPH () patients, and healthy subjects ()	In vivo	↓GSH-Px	Zachara et al. (2005) [109]
LC	A/J mice (female )	In vivo	↑8-OHdG	Xu et al. (1992) [119]

Abbreviations: 8-OHdG: 8-hydroxy-20–deoxyguanosine; 8-oxodG: 8-oxo-2-désoxyguanosine; PLA2: phospholipase A2; MP: myeloperoxidase; CRC: colorectal cancer; BC: breast cancer; ROM: reactive oxygen metabolites; GSH: glutathione (total, reduced); GSSG: glutathione disulfide; LC: lung cancer; MDA: malondialdehyde; TAC: total antioxidant capacity; PC: prostate cancer.