Redox Homeostasis and Prospects for Therapeutic Targeting in Neurodegenerative Disorders

Table 1

Natural compounds with therapeutic action against neurodegeneration disorders.

Compounds	Therapeutic target	Mechanism of action	Reference
Coenzyme q10	PD	α-Tocopheroxyl radical reduction and regeneration of α-tocopherol; Suppression of nigrostriatal dopaminergic cell death	[9, 110, 113]
Luteolin	PD	Increases dopamine uptake	[139]
Resveratrol	PD, AD	Nrf2 activation	[115, 116, 123, 135]
Curcumin	PD	Nrf2 activation	[123]
Epigallocatechin gallate	PD	Nrf2 activation	[123]
α-Tocopherol	AD	Proteolytic degradation of Aβ plaques	[130–133]
Quercetin	PD	Scavenges hydroxyl radicals	[140]
Selenium	AD	Proteolytic degradation of Aβ plaques	[130–133]
8-Hydroxyquinoline derivative	AD	Inhibit Aβ fibril formation and aggregation	[82]
N-(4-Phenoxybenzyl) aniline derivative	AD	Inhibition of acetylcholinesterase	[137]