BMSC-Derived Exosomes Ameliorate LPS-Induced Acute Lung Injury by miR-384-5p-Controlled Alveolar Macrophage Autophagy

Figure 6

Exosomes alleviated LPS-induced lung injury and attenuated pulmonary vascular permeability in ALI rats. (a) Rat survival rate of 7 days was evaluated by Log-rank (Mantel-Cox) test. (b) H&E staining was used for evaluating the pathological changes in the lung. The image revealed that LPS caused pathological changes in lung tissue, and the administration of the exosomes attenuated lung injury (×100 magnification). (c) The quantitative analysis of the lung injury scores in each group. Lung injury score of LPS-exposed lung turned to be higher than the sham group, while the score was decreased after exosome administration. (d) ratio in different groups. ratio of the LPS-exposed lung turned to be higher than the sham group, while the ratio was decreased after exosome administration. (e) The quantitative analysis of Evans blue dye leakage. This result was similar to that of the ratio, suggesting that exosomes could improve lung vascular permeability impaired by LPS. Values obtained from three independent experiments are expressed as and compared using ANOVA followed by LSD test. vs. the sham group; vs. the sham group; ^# vs. the LPS group; ^## vs. the LPS group.

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