Protection against Doxorubicin-Related Cardiotoxicity by Jaceosidin Involves the Sirt1 Signaling Pathway

Figure 3

Jaceosidin (4 mg/kg) inhibited doxorubicin- (DOX-) related cardiac injury in vivo. (a) Body weight (). (b) The ratio of heart weight (HW) to tibia length (TL) (). (c, d) The plasma levels of cardiac troponin I (cTnI) and lactate dehydrogenase (LDH) (). (e) Ejection fraction (EF) in the mice (). (f, g) Left ventricular end-diastolic pressure (LVEDP) and the alteration in +dP/dt (). (h) The alteration in stroke work (). (i) Cardiomyocytes vacuolization were evaluated by HE staining. Mice were intraperitoneally injected with a single dose of DOX (15 mg/kg) to establish the acute cardiac injury model. Five days after DOX injection, blood samples and heart tissues were collected to assess cardiac injury, as reflected by (a–h). Data are shown as . Comparisons between multiple groups were performed using one-way ANOVA followed by a post hoc Bonferroni comparison analysis. compared with saline. compared with DOX alone.

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