Protection against Doxorubicin-Related Cardiotoxicity by Jaceosidin Involves the Sirt1 Signaling Pathway

Figure 7

Jaceosidin (4 mg/kg) did not provide cardiac protection in mice with sirtuin 1 (Sirt1) inhibition. (a) Ejection fraction (EF) in DOX-treated mice (). (b) The level of cardiac troponin I (cTnI) in DOX-treated mice (). (C) +dP/dt in DOX-treated mice (). (d) The levels of 4-hydroxynonenal (4-HNE) in DOX-treated mice (). (e, f) The levels of tumour necrosis factor- (TNF-) α and interleukin- (IL-) 6 in DOX-treated mice (). (g) The activity of caspase-3 in mice (). To inhibit Sirt1 in vivo, mice were subjected to a specific inhibitor of Sirt1 (Ex527, 1 mg/kg) every other day for a total of 8 days beginning 3 days before DOX injection. Data are shown as . Comparisons were performed using one-way ANOVA followed by a post hoc Bonferroni comparison analysis. versus the matched control.

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