Insight into Crosstalk between Ferroptosis and Necroptosis: Novel Therapeutics in Ischemic Stroke

Figure 3

The mechanisms of signaling crosstalk between ferroptosis and necroptosis in ischemic stroke. Cysteine, HSP90, and MPTP opening are the positive factors of necroptosis; HSP90 and MPTP opening accelerate ferroptosis, while cysteine suppresses ferroptosis by promoting GSH formation.