Melatonin Ameliorates Valproic Acid-Induced Neurogenesis Impairment: The Role of Oxidative Stress in Adult Rats

Figure 2

Images of p21-positive cells (green) in the SGZ of the hippocampal DG by group (a–d). All nuclei were counterstained with propidium iodide (red). Arrowheads indicate p21-positive cells in the DG (scale bars: 100 μm). The inserted figures show p21 immunostaining at high magnification (scale bars: 50 μm). The number of p21-positive cells was significantly lower in the VPA group than in the control, melatonin, and preventive groups (, (e)).

(a)

(b)

(c)

(d)

(e)