Capecitabine Regulates HSP90AB1 Expression and Induces Apoptosis via Akt/SMARCC1/AP-1/ROS Axis in T Cells

Figure 1

Quantitative proteomic and phosphoproteomic analysis revealed that CAP inhibits HSP90AB1 and SMARCC1 protein expression in vivo. Normal mice were administered metronomic doses of CAP (100 mg/kg/d). On days 0, 7, 14, and 21, the spleen was collected for quantitative proteomic and phosphoproteomic analysis. (a) Volcanic map of differentially expressed proteins (DEPs) in quantitative proteomic analysis on days 7, 14, and 21 (compared with day 0). (b) Volcanic map of DEPs in phosphoproteomic analysis on days 7, 14, and 21 (compared with day 0). Subsequently, association analysis of quantitative proteomic and phosphoproteomic analysis results was performed. (c–e) Heat map of DEPs in both quantitative proteomic and phosphoproteomic analyses on days 7, 14, and 21.

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