Capecitabine Regulates HSP90AB1 Expression and Induces Apoptosis via Akt/SMARCC1/AP-1/ROS Axis in T Cells

Figure 8

Scheme summarizing the apoptosis of T cells induced by CAP via HSP90AB1/Akt/SMARCC1/AP-1/ROS axis. After oral administration, CAP is converted into 5DFCR and 5DFUR by CES and CDA in the liver. In T cells, which expressed TP, 5DFUR can finally be converted into 5-FU; CAP reduces HSP90AB1, Akt, SMARCC1, c-Fos, c-Jun, GCLC, GCLM, and HO-1 expression, reduces the GSH level, increases the ROS level, and finally induces apoptosis.