Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives
Table 4
Different biological activities of diosgenin and their derivatives with the mechanism of action.
Disease
Experimental model
Mechanism
Pharmacological action
References
Cardiac fibrosis
Rat cardiac fibrosis cells in vitro μM
↓ α-SMA ↓ TGF-β1 ↓ p-Smad3
↓ proliferation of Ang II-induced cardiac fibrosis, ECM synthesis of rat cardiac fibrosis and expression of TGF-beta 1 and Smad3 phosphorylation in cardiac fibrosis cells
Diosgenin treatment significantly inhibited the apoptosis and upregulated the mitochondrial oxidative stress capacity of chondrocytes in experimental mice with osteoarthritis