Intervertebral Disc Degeneration and Low Back Pain Depends on Duration and Magnitude of Axial Compression

<div>Mechanical stress caused gradual IDD and LBP in NPCs. (a, b) NPCs exhibited gradual downregulated expression of ECM-related gene of aggrecan and upregulated expression of IDD-related gene of MMP3, with a time-response manner. (c, d) NPCs had significantly upregulation of LBP-related gene of CGRP and substance P, with a time-response manner. 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One-way ANOVA and Tukey’s HSD multiple comparison test were used for statistical analysis).</div>

Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: Intervertebral Disc Degeneration and Low Back Pain Depends on Duration and Magnitude of Axial Compression 