Nutrition Interventions of Herbal Compounds on Cellular Senescence

Figure 2

The main regulators of the cell cycle and their functions in senescence. The cyclin-dependent kinase inhibitors p16^INK4A and p21^Cip1 are commonly used markers of senescence. Cell cycle arrest is induced by the inhibition of cyclin-dependent kinases (CDKs) through the p53/p21^Cip1 and/or Rb/p16^INK4A pathways, which causes sustained DNA damage.